PowerPoint: Post-Genomic Possibilities

So far, we are no where near 10,000 new drugable targets. PowerPoint slide from 2002 Chips to Hits Conference in Boston.

Quest for Genomic Testing

An article in The New York Times, and a separate piece in The Motely Fool, take a look at Quest Diagnostics, the Lyndhurst, N.J.-based medical-testing giant. The Times examines growth prospects Quest and the other publicly held companies in the field of medical lab testing. Three of the four companies in the sector – Quest, LabCorp, LabOne – have been trading at near 52-week highs. These three, together with Speciality Laboratories, do as much as one quarter of the testing in the US, The Times said, quoting Robert Michel, who writes an industry newsletter. Significant growth may come from new genomic tests.

"If the industry agrees on anything, it is the opportunity presented by diagnostic tests being developed to assess illness, or even the risk of future illness, by analyzing a patient's DNA and RNA, the storehouses of genetic information. New and nonroutine tests are the only part of the business consistently growing at double-digit rates," writes Times reporter Barnaby J. Feder.

Medical testing is a $41 billion market with single-digit growth. But genomic testing, while an emerging sector, is producing double-digit growth, and Quest is moving to improve its share, according to The Motley Fool. In an article published this week, the online investing publication, said genomic testing is currently required in 7 percent of all tests. Hospitals today conduct 60 percent of all testing, but may not be able to translate that dominance into the genomic testing market because of the hurdles required to install new equipment, administer the new tests and the fees and royalties required. The Fool said that last year, Quest generated $600 million, or some 12 percent of its revenues, from these types of tests. The article said that Quest, and LabCorp, with their wide coverage of the marketplace, are positioned well to take advantage of this opportunity.

New Biology Economy take – These two articles illustrate well the changes that genomic testing may bring to the healthcare marketplace. However, it is very early. There are very few scientifically proven and FDA-approved biomarkers, which must be the basis for these tests. That is where biomedicine is concentrating these days, understanding what it doesn't know, and organizing under the banner of systems biology or integrated biology, to create knowledge, and the technology to enable innovation to move from academia to the Quests and LabCorps, as well as the hospitals, to the benefit of patients. It's a tangled thicket of patents and royalties as well as being technically challenging, and one where there isn't a labor force skilled enough to handle today's volume, much less tomorrow's.